Between January 1973 and June 1992, 1852 patients were registered in the Department of Obstetrics and Gynecology, Catholic University Medical College, and 701 patients of them were received chemotherapy for gestational trophoblastic tumors, Among
these
patients. Hysterectomy(n=160), pulmonary resection(n=18), craniotomy(n=7) and others(n=7_ were performed.
@ES We analyzed these cases retrospectively and the results were as follows:
@EN 1) Initial hysterectomy for low risk GTT significantly reduced the number of courses of chemotherapy and duration of hospitalization comparing to either chemotherapy alone or chemotherapy with delayed hysterectomy.
2) If resistance develops to systemic chemotherapy. Adjuvant hysterectomy should be considered in stage I or II.
3) Although surgical role in high risk patient is considered, the effectiveness of the surgery was lower than low risk patients.
4) Thoracotomy may be attempted to excise the resistant focus and reduced the number of courses of chemotherapy and duration or hospitalization.
5) Craniotomy may be required to provide acute symptom relief and should be combined systemic chemotherapy and intrathecal MTX infusion.
6) The remarkable sensitivity of GTT to chemical treatment has not eliminated the need for surgery.
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